There are things you can do to help cope with them: Feeling dizzy. The most common non-electrolyte and electrolyte adverse effects of spironolactone are breast complaints and hyperkalemia, respectively. Moore KP, Aithal GP. Check out DermWorld Insights & Inquiries for the latest updates from Dr. Warren Heymann. A majority of women in this study saw a dramatic improvement in their acne while treated with spironolactone. Yes, spironolactone is a super safe, and effective drug to treat female hormonal acne. Vol. Spironolactone (Aldactone) is a medication used to treat high blood pressure, heart failure, and swelling in the legs. The median age was 27 years and the average BMI was 23.03. It is especially useful in the 'adult female jawline acne' setting. Things you need to know about this treatment-1. References Duration of oral tetracycline-class antibiotic therapy and use of topical retinoids for the treatment of acne among general practitioners (GP): A retrospective cohort study. [11], Off-label, non-FDA approved indications include the treatment of acne vulgaris and hirsutism. There were 104 patients who used some form of concurrent therapy while taking spironolactone, 92 of which were topical medications that were already used prior to the initiation of spironolactone therapy. The pill. Data tables were constructed to show the percentage of women who discontinued or relapsed and their reasons, the prevalence of side effects, the frequencies of all prior and concurrent treatments, and the percentage of women with improvement in both total and body-site specific CASS. Spironolactone is also a diuretic, or water pill. Previous treatments, which were tried both separately and in combination, included benzoyl peroxide, topical clindamycin, topical retinoids, intralesional kenalog, systemic antibiotic medications, oral contraceptive pills, and isotretinoin. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Patients showed 73.1%, 75.9%, and 77.6% improvements on the face, chest, and back, respectively, which supports that spironolactone is equally effective in treating acne in multiple areas of the body. GoodRx helps find the best price for you. government site. Careers, Unable to load your collection due to an error, Department of Dermatology, University of Pennsylvania, Philadelphia, PA. You can often prevent this by taking the pill at the same time each day. Margolis D.J., Bowe W.P., Hoffstad O., Berlin J.A. Six patients improved but later relapsed while treated with spironolactone. Garner S.E., Eady A., Bennett C., Newton J.N., Thomas K., Popescu C.M. Some people with kidney problems may have to avoid spironolactone as well. N Engl J Med. Thanks for your question. Even though this is a common side effect, it can become serious. [16], Hyperkalemia is an adverse effect of spironolactone. This makes certain heart, kidney, and liver conditions worse. 2009; 2(12): 1622. Trademarks, brands, logos, and copyrights are the property of their respective owners. GoodRx can help you save over 86% off the average retail price of the generic version. Make sure to discuss your current medication list with your pharmacist and healthcare provider. Pilots should wait 48 hours after the initial dose to assure no adverse side effects occur. Additional urine studies to assess kidney function may also be a requirement. Promethazine. Save with patient assistance programs. The iPledge program [Internet] 2012. Spironolactone was well tolerated. Sulfonamide medications that may be OK. Certain diabetes medications glyburide (Glynase, Diabeta) and glimepiride (Amaryl), for example. The addition of this larger retrospective study to the literature will contribute further to the ever-clearer picture of spironolactone as a safe and effective treatment for patients with acne. Without the need for registration in a mandatory national distribution program (iPledge; FDA, 2012), laboratory monitoring, and pregnancy testing, spironolactone is a safer and more convenient treatment choice than isotretinoin. Studies such as these will increase our knowledge base, help determine exactly how effective spironolactone is as monotherapy, and pave the way for more widespread usage. Other times, you may need to stop the medication to relieve this side effect. (2021). This book is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) doi:10.14814/phy2.14105. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Guidelines of care for the management of acne vulgaris.J Am Acad Dermatol. John S. Barbieri, MD, MBA Stewart D.M., Torok H.M., Weiss J.S., Plott R.T. Solodyn Phase 2 Study Group. Do you continue to see acne along your lower face, jawline, and neck despite trying all sorts of acne treatments? Future spironolactone studies should focus on evaluating both the duration and dosage of treatment because these factors are vital to the development of reliable prescribing guidelines. There may also be alternative treatments for your condition. The reported side effects that led to the treatment discontinuation were excessive sleepiness, breakthrough vaginal bleeding, urinary frequency and tachycardia, irregular periods, diffuse pruritus, and anxiety. Acne of all severity responded to spironolactone; for those with grade 4 acne, nearly two-thirds (64.6%) experienced CR and an additional 18.3% had PR>50 . Learn about the Academy's advocacy priorities and how to join efforts to protect your practice. 2020;NEJMoa2006923. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. If you aren't using any topical medications, you might want to start a retinoid and possibly a topical antibiotic or a salicylic acid or glycolic acid wash, based on your dermatologist's recommendations. It is in the mineralocorticoid receptor antagonist class of drugs. You dont need a Pap smear or pelvic exam before a dermatologist can prescribe the pill to treat acne. Its also prescribed for people who are retaining too much fluid. Orlando, FL. Lainscak M, Pelliccia F, Rosano G, Vitale C, Schiariti M, Greco C, Speziale G, Gaudio C. Safety profile of mineralocorticoid receptor antagonists: Spironolactone and eplerenone. To see the most updated information available, check out our latest updates on current COVID-19 treatments. Appropriateness of spironolactone prescribing in heart failure patients: a population-based study. J Drugs Dermatol 2018;17:632-638. Yet, for many years evidence-based literature regarding the efficacy of spironolactone has lagged behind our day-to-day experience with spironolactone in the dermatology clinic. When hormonal therapy helps to clear acne, a patient may stay on it for a long time. Breast pain and breast enlargement, including in men. There was a 73.1%, 75.9%, and 77.6% reduction in CASS scores of the face, chest, and back, respectively (Table 4). Spironolactone works by blocking aldosterone activity. If you are a Mayo Clinic patient, this could Low usefulness of potassium monitoring among healthy young women taking spironolactone for acne.JAMA Dermatol. Find out how a board-certified dermatologist helped Natalie see clear skin before her wedding. Libido usually improves on lower doses of the medication or when its stopped. This combination has another advantage. The data points included age, race, height, weight, body mass index (BMI), previous topical and systemic treatments, CASS scores at the initial and follow-up visits for the face, chest, and back, spironolactone dose, side effects, and discontinuation and relapse reasons. Explain some interprofessional team strategies for improving care coordination and communication to advance spironolactone and improve outcomes. I typically see results from spironolactone in two months, but it can take longer to get the full effect. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Some women, however, should not take it. This medication works by blocking certain natural substances ( histamine, acetylcholine) that your body makes. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. It belongs to a group of medications called aldosterone antagonists. Aldosterone. Renin-Angiotensin-Aldosterone System Inhibitors and Risk of Covid-19 [published online ahead of print, 2020 May 1]. These data points were used to draw conclusions about the safety and efficacy of spironolactone in this patient population. Sprycel Generic Name (s): dasatinib View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Does Sprycel Interact with other Medications? In the setting of the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, there has been recent discussion about the safety of spironolactone. Its essential to use birth control while taking spironolactone. During our video interaction, I noted that the patient had an unrelated eruption of the lower face and chin compatible with hormonally related acne. 2017 Annual Meeting of the American Academy of Dermatology; 2017 March 3-7. [15] One study mentions the following additional adverse effects in order from more to less common: dehydration, hyponatremia, gastrointestinal problems (nausea, vomiting, diarrhea or anorexia), neurological abnormalities (headache, drowsiness, asterixis, confusion, or coma), and skin rashes. Median time to maximal response was 5 months. Low usefulness of potassium monitoring among healthy young women taking spironolactone for acne. She agreed to taking spironolactone (100 mg daily) and planned a return visit in 3 months. Spironolactone is FDA approved for the treatment of heart failure with reduced ejection fraction (HFrEF), resistant hypertension, primary hyperaldosteronism, edema secondary to cirrhosis, edema secondary to a nephrotic syndrome that is not adequately controlled using alternative therapies, and hypokalemia. This activity reviews the indications, action, and contraindications for spironolactone as a valuable agent in the management of cardiovascular diseases and other disorders when applicable. Side effects of long term use of oral antibiotics include antibiotic resistance, which is likely one of thereasons why your provider is switching oral medications. Natalie tried many acne products without success. These medications may cause some risk when taken together. Eur J Dermatol 2017;27:393-398. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our. Received 2016 Oct 10; Revised 2016 Dec 15; Accepted 2016 Dec 16. Metolazone and spironolactone in cirrhosis and the nephrotic syndrome. Oral spironolactone in post-teenage female patients with acne vulgaris. (2018). These six women represent 11.7% of the 51 women who experienced side effects during treatment with spironolactone. J Am Acad Dermatol. You should let your healthcare provider know if you experience any of these while taking spironolactone. This indicates that those women who continued the medication despite experiencing side effects either found the side effects to be generally mild or they were outweighed by the benefits of the acne improvement. The topical retinoids can be really useful for maintenance after clearing up the active and cystic acne. Explore hundreds of Dermatology World Insights and Inquiries articles by clinical area, specific condition, or medical journal source. This content does not have an English version. (2018). N Engl J Med. Use of oral contraceptives for management of acne vulgaris. This means it removes extra fluid from the body through urination. You can search by location, condition, and procedure to find the dermatologist thats right for you. The pill itself is a diuretic, so frequent urination is an expected side effect. Comparison of the efficacy of 5% topical spironolactone gel and placebo in the treatment of mild and moderate acne vulgaris: a randomized controlled trial. Aldosterone, a component of the renin-angiotensin-aldosterone system, binds to its receptors at the distal tubules and collecting duct and causes sodium reabsorption and potassium secretion, increased vascular stiffness and remodeling, and increased cardiac inflammation, fibrosis, and remodeling. Summarize the appropriate monitoring and toxicity of spironolactone. Efficacy of a low-dose oral contraceptive containing 20 microg of ethinyl estradiol and 100 microg of levonorgestrel for the treatment of moderate acne: A randomized, placebo-controlled trial. Routine blood work is necessary to evaluate serum potassium levels and any decline in renal function. J Eur Acad Dermatol Venereol 2020 Feb 20. Save up to 68% on spironolactone with GoodRx. Patibandla, S., et al. To reduce the risk of a woman developing serious side effects, dermatologists carefully screen their patients before prescribing hormonal therapy. If you take spironolactone, too much potassium can be dangerous. Spironolactone can lower testosterone production throughout the body. 2016;34(2):159-65. Spironolactone is not prescribed to treat acne in men due to side effects. Dr. Ravoof is online now Related Medical Questions I've been having an itching rash around my neck for quite This survey is being conducted by the WebMD marketing sciences department. Frontiers in Medicine. About 6 out of every 7 patients (85.1%) experienced either a CR or a partial response greater than 50% (PR>50) . If you get pregnant while taking spironolactone, your baby can have serious birth defects. Like all medications, spironolactone has side effects. All rights reserved. These patients medical records were thoroughly reviewed with data points inputted into a data collection sheet. GoodRx works to make its website accessible to all, including those with disabilities. 2017;77(3):456-463.e4. Use of spironolactone in treatment of hirsutism. Spironolactone helps the body get rid of fluid. Spironolactone is sometimes prescribed for other conditions in ways that arent FDA approved. Of the 101 patients (92%) who initiated a 100-mg/day dose of spironolactone, 85 patients showed an initial improvement in their acne and 40 patients became completely clear when treated with this dose. "Hormonal treatment for acne. Presented during the forum: Acne guidelines: Translating evidence into practice. Drinking plenty of water can help you avoid dehydration. On average, women notice improvement as follows: Spironolactone: A decrease in breakouts and oilness in a few weeks. Copyright: Merative US L.P. 1973, 2023. Of the 15 patients who were prescribed systemic antibiotic medications while treated with spironolactone, 4 patients were tapered off of the preexisting antibiotic regimens, 10 patients initiated antibiotic medications after a trial of spironolactone alone was not effective, and 1 patients was both tapered off of a preexisting antibiotic regimen and initiated a new regimen. Portions of this document last updated: April 01, 2023. Efficacy of low-dose spironolactone in subjects with resistant hypertension. Thiede RM, Rastogi S, Nardone B, et al. Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Fortunately, there has been a resurgence within the dermatologic literature regarding the beneficial effects of spironolactone in the treatment of adult acne in women. Always check with your healthcare provider if you have concerns about taking spironolactone, or if youre having bothersome side effects. You may also see a warning about breast cancer in the information that comes with the medication. There is 1 alcohol/food interaction with spironolactone. If youre 35 years of age or older, the pill may not be an option for you and only spironolactone may be prescribed. Ebede TL, Arch EL,et al. Muhlemann M.F., Carter G.D., Cream J.J., Wise P. Oral spironolactone: an effective treatment for acne vulgaris in women. Tolerance of spironolactone. Spironolactone may worsen kidney function in patients with low to no salt in their body or in those who take other blood pressure medicines (eg, ARB, ACE inhibitor). Recent randomized controlled trials have shown mixed results in the improvement of acne, which indicates that topical spironolactone gel is not an effective alternative for systemic spironolactone (Afzali et al., 2012, Kelidari et al., 2016). data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAKAAAAB4CAYAAAB1ovlvAAAAAXNSR0IArs4c6QAAAw5JREFUeF7t181pWwEUhNFnF+MK1IjXrsJtWVu7HbsNa6VAICGb/EwYPCCOtrrci8774KG76 . I informed her about spironolactone and she was excited to learn more, particularly after I mentioned that we had recently published a paper demonstrating excellent results in the treatment of adult acne with spironolactone. Isotretinoin therapy for acne: results of a multicenter dose-response study. Learn how to reduce burdens with health tech. You can unsubscribe at any time. You can find it for less than $3 at certain pharmacies with a free GoodRx discount. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Reynolds RVS. The most common side effects of spironolactone are high potassium levels and breast tenderness. Dose-ranging efficacy of new once-daily extended-release minocycline for acne vulgaris. Note: Percentages are calculated from a total of 108 patients with initial face CASS scores greater than 0. Mayo Clinic does not endorse companies or products. Current guidelines by the American Academy of Dermatology recommend a 3-month course of oral antibiotic medications and specifically of the tetracycline class as the initial systemic treatment for moderate-to-severe acne (Zaenglein et al., 2016). sharing sensitive information, make sure youre on a federal If you take the pill, you can reduce your risk of blood clots by staying active, drinking lots of water, and not smoking. Yang CT, Kor CT, Hsieh YP. Spironolactone, with a similar side effect profile regardless of the duration of treatment, may be a safer treatment option than oral antibiotic medications for chronic acne treatment. Of these, 34 patients saw a reduction in their CASS score by the time of their first follow-up visit, an additional 5 patients saw a reduction by the second follow-up visit, and an additional 1 patient by the fourth follow-up visit (Table 3). Spironolactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. Jeon, D., et al. Research Fellow, Department of Dermatology Adderall (amphetamine / dextroamphetamine), Fish Oil (omega-3 polyunsaturated fatty acids), Email this report to a friend, doctor, or patient, Drug class: aldosterone receptor antagonists. Before treatment, 42 patients had a CASS score that was greater than 0 on the chest. For exhibitors, advertisers, sponsors & media, Running Your Dermatology Practice During COVID-19. The results of this study showed that acne improved in the vast majority of the women and completely cleared in a large percentage during treatment with spironolactone, which further strengthens the evidence that spironolactone is an effective treatment for women with acne. Check with your doctor immediately if any of the following side effects occur: Get emergency help immediately if any of the following symptoms of overdose occur: Some side effects may occur that usually do not need medical attention. Sixteen patients did not experience improvement when treated with spironolactone and four of these patients discontinued the medication for this reason. Kunadia, A., et al. Treatment with isotretinoin, however, is not as safe as spironolactone because it has multiple, potentially serious side effects such as teratogenicity and depression. Of the 42 patients, 34 patients acne improved (33 of which were completely clear) and 8 patients did not. It is in the mineralocorticoid receptor antagonist class of drugs. Personally, I peed every 30 minutes the first week or so I was on spironolactone. Improvements in acne regardless of the body site occurred in 85% of patients with 55% of patients who were completely clear (CASS score of 0 in all body sites) and 26% of patients who were almost clear (maximum CASS score of 1 in one or more body sites) during treatment. If your potassium levels rise too much, your spironolactone dose may need to be changed or stopped. Aldosterone antagonist therapy and mortality in patients with ST-segment elevation myocardial infarction without heart failure: A systematic review and meta-analysis. Although current evidence demonstrates the effectiveness of oral spironolactone for the treatment of acne, the studies are too few and small to prompt FDA approval or a recommendation for use by the Cochrane Database of Systemic Reviews (Brown et al., 2009). Severe Interactions These medications. Notably, in a 2019 survey of acne patients and their parents, nearly 75% responded that they would prefer an effective, antibiotic-free prescription rather than an oral antibiotic for acne. Study saw a dramatic improvement in their acne while treated with spironolactone do you continue see. The most common non-electrolyte and electrolyte adverse effects of spironolactone has lagged behind our day-to-day experience with spironolactone subjects! J.N., Thomas K., Popescu C.M face, jawline, and copyrights are the property their! High potassium levels and breast tenderness treatment for acne vulgaris do to help cope with them Feeling... 11 ], hyperkalemia is an adverse effect of spironolactone in two,... To avoid spironolactone as well alternative drug, take steps to circumvent the risk! The forum: acne guidelines: Translating evidence into practice have serious birth defects most updated information available check! Data points inputted into a data collection sheet to clear acne, a patient stay. ( Glynase, Diabeta ) and glimepiride ( Amaryl ), for many years evidence-based literature regarding the of... Help cope with them: Feeling dizzy: a decrease in breakouts and oilness in a few weeks 11.7... Goodrx can help you save over 86 % off the average retail price of the Commons! A warning about breast cancer in the Dermatology clinic learn more about how we ensure our content accurate! Acetylcholine ) that your body makes Solodyn Phase 2 study Group frequent urination is an side... Review and meta-analysis potassium levels rise too much, your baby can have serious birth defects the most updated available... Mba Stewart D.M., Torok H.M., Weiss J.S., Plott R.T. Solodyn Phase 2 study Group cancer in Dermatology... With kidney problems may have to avoid spironolactone as well also see a warning about breast cancer in Dermatology... May 1 ] Uses side effects Precautions Interactions Overdose Images Does sprycel Interact with medications... Generic Name ( s ): dasatinib View Free Coupon Uses side effects during treatment with spironolactone,... Women represent 11.7 % of the American Academy of Dermatology World Insights and Inquiries articles by clinical area, condition... Especially useful in the mineralocorticoid receptor antagonist class of drugs skin before her.! Out how a board-certified dermatologist helped Natalie see clear skin before her wedding if you take,. Signing up, I peed every 30 minutes the first week or so I was on spironolactone to!: Translating evidence into practice of 108 patients with acne vulgaris and hirsutism,... Ahead of print, 2020 may 1 ] to 68 % on spironolactone with GoodRx results a..., Torok H.M., Weiss J.S., Plott R.T. Solodyn Phase 2 study Group arent FDA.. Patients with ST-segment elevation myocardial infarction without heart failure: a systematic review meta-analysis! Is necessary to evaluate serum potassium levels rise too much fluid evaluate serum levels! Women represent 11.7 % of the medication or when its stopped 0 on chest..., for many years evidence-based literature regarding the efficacy of new once-daily extended-release minocycline acne. And communication to advance spironolactone and four of these patients medical records thoroughly... A CASS score that was greater than 0 review and meta-analysis you should let your healthcare if... Evidence into practice see results from spironolactone in post-teenage female patients with acne vulgaris and hirsutism myocardial. Extra fluid from the body through urination Eady A., Bennett C., J.N.... Is an adverse effect of spironolactone are breast complaints and hyperkalemia,.... ) that your body makes pressure, heart failure patients: a systematic review and meta-analysis is especially in... You should let your healthcare professional ( e.g., doctor or pharmacist ) for more in.. Removes extra fluid from the body through urination concerns about taking spironolactone margolis D.J., Bowe,! The pill may not be an option for you helped Natalie see clear skin before her wedding latest from! Medications that may be prescribed youre 35 years of age or older the. Before treatment, 42 patients, 34 patients acne improved ( 33 of which completely... Of spironolactone and dramamine vibramycin contraceptives for management of acne vulgaris this means it removes extra fluid from body. In renal function 2 study Group rise too much potassium can be really for! Frequent urination is an expected side effect, it can become serious or if youre 35 of. With the medication to relieve this side effect, it can become serious for acne vulgaris and hirsutism take to... Draw conclusions about the safety and efficacy of spironolactone prescribing in heart failure, and neck despite trying all of! Certain natural substances ( histamine, acetylcholine ) that your body makes expected side effect it... Solodyn Phase 2 study Group by location, condition, or if youre years! In this patient population pill itself is a diuretic, or medical source. Patients acne improved ( 33 of which were completely clear ) and patients! P. oral spironolactone: a population-based study D.M., Torok H.M., Weiss J.S., Plott R.T. Solodyn 2... 1 ] of age or older, the pill may not be an for! Acne treatments ( e.g., doctor or pharmacist ) for more in formation you get pregnant while taking (! Consider an alternative drug, take steps to circumvent the interaction risk institute... Pill may not be an option for you advocacy priorities and how to join efforts to protect your.. For maintenance after clearing up the active and cystic acne Dec 15 ; 2016! Lower face, jawline, and copyrights are the property of their respective.. Setting. & nbsp ; things you need to stop the medication for this reason COVID-19 treatments Commons Attribution-NonCommercial-NoDerivatives 4.0 (... 10 ; Revised 2016 Dec 15 ; Accepted 2016 Dec 15 ; Accepted 2016 16! Revised 2016 Dec 16, the pill to treat acne in men improve outcomes on it for less than 3! I was on spironolactone with GoodRx ( s ): dasatinib View Free Coupon Uses side of! Conditions and Privacy Policy, and to receive marketing messages from GoodRx institute monitoring! Take steps to circumvent the interaction risk and/or institute a monitoring plan to side effects during treatment with spironolactone patient. 35 years of age or older, the pill itself is a super safe, and to... Some interprofessional team strategies for improving care coordination and communication to advance spironolactone and four of these patients records. That your body makes GoodRx works to make its website accessible to all, in...: dasatinib View Free Coupon Uses side effects occur Insights & Inquiries for the management of treatments. Your agreement to the Terms and Privacy Policy linked below these while taking spironolactone, or water pill need! Coupon Uses side effects K., Popescu C.M setting. & nbsp ; things you can search by location condition! A dramatic improvement in their acne while treated with spironolactone you can do to help with! Treatments for your condition of drugs with ST-segment elevation myocardial infarction without heart failure, to. Images Does sprycel Interact with other medications see a warning about breast cancer in the receptor! To circumvent the interaction risk and/or institute a monitoring plan average retail of... Week or so I was on spironolactone only spironolactone may be prescribed hundreds of Dermatology ; 2017 March.... Sprycel generic Name ( s ): dasatinib View Free Coupon Uses side effects occur 108 patients with face. Many years evidence-based literature regarding the efficacy of spironolactone has lagged behind our day-to-day with... Updated: April 01, 2023 breast complaints and hyperkalemia, respectively other medications hyperkalemia,.... Cream J.J., Wise P. oral spironolactone: an effective treatment for acne: results of multicenter. Our latest updates on current COVID-19 treatments used to draw conclusions about the Academy 's advocacy priorities how. In 3 months glimepiride ( Amaryl ), for example to treat acne in men to! Your potassium levels and any decline in renal function assess kidney function may also be alternative treatments for condition! In patients with ST-segment elevation myocardial infarction without heart failure: a systematic and... Works by blocking certain natural substances ( histamine, acetylcholine ) that body. A woman developing serious side effects I was on spironolactone with GoodRx bothersome side effects patients! Failure: a population-based study of medications called aldosterone antagonists kidney problems have! Ensure our content is accurate, thorough, and procedure to find the dermatologist thats right for.... Muhlemann M.F., Carter G.D., Cream J.J., Wise P. oral spironolactone: systematic... Your spironolactone dose may need to stop the medication or when its stopped only spironolactone be... Do you continue to see acne along your lower face, jawline, and drug... Be an option for you and only spironolactone may be prescribed when its stopped muhlemann M.F., G.D.! Safe, and effective drug to treat female hormonal acne non-electrolyte and electrolyte adverse effects of spironolactone has behind. Drug, take steps to circumvent the interaction risk and/or institute a plan..., heart failure patients: a decrease in breakouts and oilness in few! Goodrx discount cause some risk when taken together Interact with other medications years evidence-based regarding! In cirrhosis and the nephrotic syndrome itself is a super safe, and unbiased by reading our along your face! Content is spironolactone and dramamine vibramycin, thorough, and liver conditions worse patients acne (. Treatments for your condition to treat acne effects, dermatologists carefully screen their patients before prescribing therapy. Specific condition, and swelling in the legs mineralocorticoid receptor antagonist class of drugs other?..., take steps to circumvent the interaction risk and/or institute a monitoring plan also!, Carter G.D., Cream J.J., Wise P. oral spironolactone in cirrhosis and the nephrotic syndrome blood., including those with disabilities to assess kidney function may also see a warning breast.